Assailants have shot dead five Egyptian policemen in Badrasheen, a town south of Cairo, the interior ministry has told AFP news agency.
It is the latest of a series of attacks targeting the country's security forces, AFP adds.
The ministry told AFP that three gunmen opened fire on a police car and then fled.
There was no immediate claim of responsibility.
However, jihadist militants have killed hundreds of police and soldiers since the military overthrew Islamist President Mohammed Morsi in 2013.