Eden Hazard has fully recovered from a fractured ankle and could make his first Chelsea start of the season.
Captain Gary Cahill might return to the side after impressing in midweek, but midfielder Danny Drinkwater is out with a calf injury until next month.
Arsenal forward Theo Walcott is likely to miss out after sustaining a calf problem in the Europa League.
Midfielder Francis Coquelin is missing with a hamstring strain, while Santi Cazorla is still sidelined.
Arsenal took only nine points from their 10 games against the other top six sides last season. To put that into context, Chelsea took 16 and Liverpool 20 - the Merseysiders were the most successful team in that mini-league.
"In short, Arsenal must do better against their rivals - certainly much better than at Anfield three weeks ago.
"Chelsea have hit their stride after the shock defeat to Burnley and look to be London's most likely title challengers.
"It has been six years since Arsenal avoided defeat at the Bridge - with the Gunners conceding 15 goals and scoring only two along the way. Chelsea will be strong favourites to win again, and take some revenge for their double-denying FA Cup final defeat in May."
Chelsea head coach Antonio Conte: "I think that Arsenal is one of the six top teams in England and I think that they have a really good squad and want to fight for something important.
"For this reason, I think it is a massive game for us. When you play against Arsenal it is the same as when you play against [Manchester] City, Liverpool, [Manchester] United or Tottenham.
"Arsenal are a big rival. I don't understand why they can't fight for the title."
Arsenal manager Arsene Wenger: "If you look at my record you will see that I played two years in England, in the Premier League, without losing games away from home.
"Last year, until we lost at Everton, we had not lost away for the whole year.
"Never in my life could I accept or understand that it is different away from home. It's just a question of how much you want it."