Arsenal travel to face the champions at Stamford Bridge less than three days after playing in the Europa League.
The Gunners face Cologne at the Emirates tomorrow night (8.05pm).
And Wenger is set to make wholesale changes to his side with an eye on Sunday’s London derby (1.30pm).
Chelsea have five days to prepare, having beaten Qarabag 6-0 at home in the Champions League last night.
But Arsenal’s under-pressure manager is not using tomorrow’s contest as an early excuse in case things go wrong at Chelsea.
“We played on Wednesday night in Barcelona and against Everton on Saturday morning.
Arsenal cannot afford another poor performance against a big rival, having lost 4-0 at Liverpool last month.
They bounced back at the weekend with a 3-0 victory over Bournemouth.
However, Gunners supporters are desperate to see Wenger’s side impress when they face Chelsea.