Wayne Rooney will return to Old Trafford for the first time since his summer departure when Everton take on Premier League (EPL) leaders Manchester United in the second part of a sumptuous double-header on Sunday.
Preceding the clash in Manchester is champions Chelsea's meeting with Arsenal, the Gunners having bounced back from back-to-back defeats with a 3-0 win over Bournemouth last time out.
Liverpool need a response when they host Burnley at Anfield on Saturday having been thrashed 5-0 by Manchester City last weekend, while Pep Guardiola's Sky Blues will look to continue their momentum at Watford.
Here is the full fixture list for Week 5 of the 2017-18 Premier League season, along with viewing information and predictions for each game:
Saturday, September 16
12:30 p.m. BST/7:30 a.m. ET: Crystal Palace vs. Southampton (1-2) on Sky Sports/NBC
3 p.m. BST/10 a.m. ET: Huddersfield Town vs. Leicester City (2-2) on NBC
3 p.m. BST/10 a.m. ET: Liverpool vs. Burnley (2-1) on NBC
3 p.m. BST/10 a.m. ET: Newcastle United vs. Stoke City (1-1) on NBC
3 p.m. BST/10 a.m. ET: Watford vs. Manchester City (1-3) on NBC
3 p.m. BST/10 a.m. ET: West Bromwich Albion vs. West Ham United (2-0) on NBC
5:30 p.m. BST/12:30 p.m. ET: Tottenham Hotspur vs. Swansea City (4-1) on Sky Sports/NBC
Sunday, September 17
1:30 p.m. BST/8:30 a.m. ET: Chelsea vs. Arsenal (2-1) on Sky Sports/NBC
4 p.m. BST/11 a.m. ET: Manchester United vs. Everton (1-0) on Sky Sports/NBC