As well as debutants Saint George of Ethiopia in Group C they will face Esperance of Tunisia and DR Congo's AS Vita Club, who have both been continental champions in the past.
Sudan's two biggest clubs have been draw in Group A as Al Hilal and Al Merreikh are joined by Etoile du Sahel of Tunisia and Mozambique's Ferroviario Beira.
|African Champions League:|
|Group A||Group B|
|Etoile du Sahel (Tunisia)||Zamalek (Egypt)|
|Al Hilal (Sudan)||USM Alger (Algeria)|
|Al Merreikh (Sudan)||Al Ahly Tripoli (Libya),|
|Ferroviario Beira (Mozambique)||CAPS Utd (Zimbabwe)|
|Group C||Group D|
|Mamelodi Sundowns (South Africa, holders)||Al Ahly (Egypt)|
|Esperance (Tunisia)||Wydad Casablanca (Morocco)|
|AS Vita Club (DR Congo)||Coton Sport (Cameroon)|
|Saint George (Ethiopia)||Zanaco (Zambia)|
The reward for Zimbabwean debutants CAPS United, who beat five-time champions TP Mazembe of DR Congo, is three trips to North Africa.
They are in Group B alongside last year's runners-up Zamalek from Egypt, Algeria's USM Alger and Al Ahly Tripoli of Libya.
The first group games will be played on the weekend of 12-14 May with the top two teams in each group progressing to the quarter-finals.
The first leg of the final is set for the last weekend in October and the second leg being played a week later.